Figure 3-2: Hematopoiesis

Regulation of hematopoiesis by cytokines that stimulate the proliferation and/or differentiation of various hematopoietic cells. In the absence of infection, bone-marrow stromal cells are the major source of hematopoietic cytokines. In the presence of infection, cytokines produced by activated macrophages and T-helper cells induce additional hematopoietic activity, resulting in rapid expansion of white blood cells that participate in fighting infection. IL = interleukin; CSF = colony-stimulating factor; EPO = erythropoietin. Stem cells are shown in blue; progenitor and immune cells in purple; stromal cell in yellow; and mature differentiated cells in tan.


© 1997, Duane W. Sears


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Immunology, January, 1997

Last Updated: June 24, 1997